Stineke van Houte
I am researching antibiotic resistance, and how we might remove antibiotic resistance genes using CRISPR as a biotechnology. For my PhD, I am being supervised by Dr Will Gaze (University of Exeter Medical School) and Dr Stineke van Houte.
Previously, during my MRes degree, I worked on the interplay of Restriction-Modification and CRISPR-Cas under the supervision of Dr Edze Westra.
My project focuses on the removal of antimicrobial resistance genes from bacterial communities found in the human gut, using CRISPR-Cas9 gene editing. For this, I am focusing on clinically relevant vancomycin-resistant enterococci, as well as multidrug resistant Enterobacteriaceae. I am supervised by Stineke van Houte, Edze Westra and Will Gaze (University of Exeter Medical School).
During my PhD (ToxAlim, Université de Toulouse, France), I characterised the biochemical activity of the Cytolethal Distending Toxin, a genotoxin produced by pathogenic bacteria. I joined Dr van Houte’s group to work on bacteriophages-encoded proteins (anti-CRISPR proteins, Acr) that inhibit bacterial CRISPR-Cas systems. My project focuses aims to better understand how Acr biochemical activity shapes phage-bacteria relationship and impacts coevolution between the virus and its host.