Stineke van Houte
I am researching antibiotic resistance, and how we might remove antibiotic resistance genes using CRISPR as a biotechnology. For my PhD, I am being supervised by Dr Will Gaze (University of Exeter Medical School) and Dr Stineke van Houte.
Previously, during my MRes degree, I worked on the interplay of Restriction-Modification and CRISPR-Cas under the supervision of Dr Edze Westra.
My project focuses on the removal of antimicrobial resistance genes from bacterial communities found in the human gut, using CRISPR-Cas9 gene editing. For this, I am focusing on clinically relevant vancomycin-resistant enterococci, as well as multidrug resistant Enterobacteriaceae. I am supervised by Stineke van Houte, Edze Westra and Will Gaze (University of Exeter Medical School).
My research focuses on the coevolutionary dynamics between bacteria with CRISPR-Cas immunity and their lytic phages. Using Streptococcus thermophilus and phage 2972 as a model system, I am investigating whether the hypothesised arms race caused by CRISPR spacer acquisition and phage protospacer mutation can lead to coevolution between both species. My supervisors are Stineke van Houte, Edze Westra and Angus Buckling.