Stineke van Houte
Principal Investigator
David Sünderhauf
PhD Student
I am researching antibiotic resistance, and how we might remove antibiotic resistance genes using CRISPR as a biotechnology. For my PhD, I am being supervised by Dr Will Gaze (University of Exeter Medical School) and Dr Stineke van Houte.
Previously, during my MRes degree, I worked on the interplay of Restriction-Modification and CRISPR-Cas under the supervision of Dr Edze Westra.
You can also find me on Twitter (@davvi36) and Researchgate, or my contact details on the University webpages.
Ellie Pursey
PhD Student
My project focuses on the removal of antimicrobial resistance genes from bacterial communities found in the human gut, using CRISPR-Cas9 gene editing. For this, I am focusing on clinically relevant vancomycin-resistant enterococci, as well as multidrug resistant Enterobacteriaceae. I am supervised by Stineke van Houte, Edze Westra and Will Gaze (University of Exeter Medical School).
Twitter @ElliePursey
During my PhD (ToxAlim, Université de Toulouse, France), I characterised the biochemical activity of the Cytolethal Distending Toxin, a genotoxin produced by pathogenic bacteria. I joined Dr van Houte’s group to work on bacteriophages-encoded proteins (anti-CRISPR proteins, Acr) that inhibit bacterial CRISPR-Cas systems. My project focuses aims to better understand how Acr biochemical activity shapes phage-bacteria relationship and impacts coevolution between the virus and its host.
van Houte Lab 